Contact Information
Entomology & Plant Pathology
Mississippi State University
Mississippi State, MS 39762-9775
TEL: (662) 325-2085
FAX: (662) 325-8837
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HOWARD W. CHAMBERS
Professor of Entomology
Department of Entomology and Plant Pathology
Mississipi State University
Mississippi State, MS 39762-9775
TEL: (601) 325-2085
FAX: (601) 325-8837
B. S., 1961 Texas A&M University, College Station
M. S., 1963 Texas A&M University, College Station
Ph.D., 1966 University of California, Berkeley
Primary Research Interests:
Toxicology of organophosphorus (OP) insecticides and related compounds,including structure-activity relationships, role of aliesterase and A-esterase in OP detoxication, resistance to OP's in insects, and reactivation of phosphorylated cholinesterase by oximes. Extensive experience in in vitro assay of esterase activity and inhibition, synthesis of OP's, carbamates and oximes, and various acute toxicity bioassays with insects. Have worked in recent past with organophosphate-induced delayed neuropathy (OPIDN) and neuropathy target esterase (NTE).
Present Teaching Responsibilities:
(1) Toxicology and Insecticide Chemistry: Undergraduate/Graduate. Survey of the chemistry, toxicity and mechanisms of action of commercial insecticides.
(2) Advanced Toxicology: Graduate. Physiological and biochemical actions, structure-activity relationships, and metabolism of pesticides, therapeutic drugs and natural toxins.
Selected Recent Publications:
Chambers, H.. 1991. Organosphosphates: An Overview. In: Organophosphates: Chemistry, Fate and Effects. J. E. Chambers and P. E. Levi, Eds. Academic Press.
Watson, A. M., H. Chambers and J. E. Chambers. 1994. An investigation of activities and paraoxon sensitivities of hepatic aliesterases in b-naphthoflavone treated rats. Toxicol. Letters. In Press.
Chambers, J. E., T. Ma, J. S. Boone and H. Chambers. (1994). Role of detoxication pathways in acute toxicity levels of phosphorothionate insecticides in the rat. Life Sci. (Accepted pending revisions; revisions submitted).
Chambers, J. E., T. Ma and H. W. Chambers. 1994. Pesticide Biochemistry and Toxicology. Vol. 9. The Metabolism of Agrochemicals in Mammals. John Wiley and Sons. In Press.